View source for 8faz


==Cryo-EM structure of the human BCDX2 complex==
<StructureSection load='8faz' size='340' side='right'caption='[[8faz]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8faz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FAZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8faz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8faz OCA], [https://pdbe.org/8faz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8faz RCSB], [https://www.ebi.ac.uk/pdbsum/8faz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8faz ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/RA51B_HUMAN RA51B_HUMAN] A chromosomal aberration involving RAD51B is found in pulmonary chondroid hamartoma. Translocation t(6;14)(p21;q23-24) with HMGA1.<ref>PMID:11978964</ref>   A chromosomal aberration involving RAD51B is found in uterine leiomyoma. Translocation t(12;14)(q15;q23-24) with HMGA2.<ref>PMID:12649198</ref> <ref>PMID:9892177</ref> 
== Function ==
[https://www.uniprot.org/uniprot/RA51B_HUMAN RA51B_HUMAN] Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway.<ref>PMID:11751635</ref> <ref>PMID:11751636</ref> <ref>PMID:11842113</ref> <ref>PMID:12441335</ref> <ref>PMID:23108668</ref> <ref>PMID:23149936</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Greene EC]]
[[Category: Jia L]]
[[Category: Meir A]]
[[Category: Olsen SK]]
[[Category: Rawal Y]]
[[Category: Ruben EA]]
[[Category: Sung P]]
[[Category: Wasmuth EV]]