View source for 8fkg


==Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and inverse agonist SR33486==
<StructureSection load='8fkg' size='340' side='right'caption='[[8fkg]], [[Resolution|resolution]] 2.12&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8fkg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FKG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FKG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.12&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=Y62:2-chloranyl-~{N}-(5-cyanopyridin-2-yl)-5-nitro-benzamide'>Y62</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fkg OCA], [https://pdbe.org/8fkg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fkg RCSB], [https://www.ebi.ac.uk/pdbsum/8fkg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fkg ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NCOR1_HUMAN NCOR1_HUMAN] Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors.<ref>PMID:14527417</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Kojetin DJ]]
[[Category: MacTavish BS]]