View source for 8fpi


==Co-structure of the Respiratory Syncytial Virus RNA-dependent RNA polymerase with MRK-1==
<StructureSection load='8fpi' size='340' side='right'caption='[[8fpi]], [[Resolution|resolution]] 2.52&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8fpi]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_respiratory_syncytial_virus_A2 Human respiratory syncytial virus A2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FPI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FPI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.52&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Y6L:4-(2-aminopropan-2-yl)-N-[4-(cyclopropyloxy)-3-methoxybenzoyl]-6-(4-fluorophenyl)pyridine-2-carbohydrazide'>Y6L</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fpi OCA], [https://pdbe.org/8fpi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fpi RCSB], [https://www.ebi.ac.uk/pdbsum/8fpi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fpi ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/L_HRSVA L_HRSVA] Displays RNA-directed RNA polymerase, mRNA guanylyl transferase, mRNA (guanine-N(7)-)-methyltransferase and poly(A) synthetase activities. The viral mRNA guanylyl transferase displays a different biochemical reaction than the cellular enzyme. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). Functions either as transcriptase or as replicase. The transcriptase synthesizes subsequently the subgenomic RNAs, assuring their capping and polyadenylation by a stuttering mechanism. The replicase mode is dependent on intracellular protein N concentration. In this mode, the polymerase replicates the whole viral genome without recognizing the transcriptional signals (By similarity).<ref>PMID:8445369</ref> 

==See Also==
*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
== References ==
<references/>
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</StructureSection>
[[Category: Human respiratory syncytial virus A2]]
[[Category: Large Structures]]
[[Category: Fischmann TO]]