View source for 8fw2


==Cryo-EM structure of full-length human NLRC4 inflammasome with C11 symmetry==
<StructureSection load='8fw2' size='340' side='right'caption='[[8fw2]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8fw2]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FW2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FW2 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fw2 OCA], [https://pdbe.org/8fw2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fw2 RCSB], [https://www.ebi.ac.uk/pdbsum/8fw2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fw2 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/NLRC4_HUMAN NLRC4_HUMAN] The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/NLRC4_HUMAN NLRC4_HUMAN] Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis (PubMed:15107016). The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria (By similarity).[UniProtKB:Q3UP24]<ref>PMID:15107016</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Berger S]]
[[Category: Faustin B]]
[[Category: Kumar N]]
[[Category: Matico RE]]
[[Category: Medley Q]]
[[Category: Miller R]]
[[Category: Ricketts MD]]
[[Category: Sharma S]]
[[Category: Somani S]]
[[Category: Steele RA]]
[[Category: Yu X]]