View source for 8fxv


==Crystal structure of human proTGF-beta2 in complex with Nb18==
<StructureSection load='8fxv' size='340' side='right'caption='[[8fxv]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8fxv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FXV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fxv OCA], [https://pdbe.org/8fxv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fxv RCSB], [https://www.ebi.ac.uk/pdbsum/8fxv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fxv ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Activation of latent transforming growth factor (TGF)-beta2 is incompletely understood. Unlike TGF-beta1 and beta3, the TGF-beta2 prodomain lacks a seven-residue RGDLXX (L/I) integrin-recognition motif and is thought not to be activated by integrins. Here, we report the surprising finding that TGF-beta2 contains a related but divergent 13-residue integrin-recognition motif (YTSGDQKTIKSTR) that specializes it for activation by integrin alphaVbeta6 but not alphaVbeta8. Both classes of motifs compete for the same binding site in alphaVbeta6. Multiple changes in the longer motif underlie its specificity. ProTGF-beta2 structures define interesting differences from proTGF-beta1 and the structural context for activation by alphaVbeta6. Some integrin-independent activation is also seen for proTGF-beta2 and even more so for proTGF-beta3. Our findings have important implications for therapeutics to alphaVbeta6 in clinical trials for fibrosis, in which inhibition of TGF-beta2 activation has not been anticipated.

A specialized integrin-binding motif enables proTGF-beta2 activation by integrin alphaVbeta6 but not alphaVbeta8.,Le VQ, Zhao B, Ramesh S, Toohey C, DeCosta A, Mintseris J, Liu X, Gygi S, Springer TA Proc Natl Acad Sci U S A. 2023 Jun 13;120(24):e2304874120. doi: , 10.1073/pnas.2304874120. Epub 2023 Jun 6. PMID:37279271<ref>PMID:37279271</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 8fxv" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Le VQ]]
[[Category: Springer TA]]