View source for 8fxy


==Cryo-EM structure of cowpox virus M2 in complex with human B7.2 (hexameric ring)==
<StructureSection load='8fxy' size='340' side='right'caption='[[8fxy]], [[Resolution|resolution]] 3.34&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8fxy]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Cowpox_virus_(Brighton_Red) Cowpox virus (Brighton Red)] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FXY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FXY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.34&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fxy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fxy OCA], [https://pdbe.org/8fxy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fxy RCSB], [https://www.ebi.ac.uk/pdbsum/8fxy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fxy ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q8QN22_CWPXB Q8QN22_CWPXB] Plays a role in immune evasion. When secreted, inhibits T-cell activation by preventing the binding of host CD80 and CD86 to soluble CTLA4 and CD28. In the infected cell, may inhibits host NF kappa B activation.[ARBA:ARBA00045309]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Adams LJ]]
[[Category: Elliott JI]]
[[Category: Fremont DH]]
[[Category: Nelson CA]]