View source for 8fy8


==5-MeO-DMT-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex==
<StructureSection load='8fy8' size='340' side='right'caption='[[8fy8]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8fy8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FY8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FY8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.79&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=J40:[(2R)-1-[oxidanyl-[(2R,3R,5S,6R)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl]+(5E,8E)-hexadeca-5,8,11,14-tetraenoate'>J40</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene>, <scene name='pdbligand=YFW:2-(5-methoxy-1H-indol-3-yl)-N,N-dimethylethan-1-amine'>YFW</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fy8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fy8 OCA], [https://pdbe.org/8fy8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fy8 RCSB], [https://www.ebi.ac.uk/pdbsum/8fy8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fy8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GBB1_HUMAN GBB1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.<ref>PMID:18611381</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Capper MJ]]
[[Category: Wacker D]]
[[Category: Warren AL]]
[[Category: Zilberg G]]