View source for 8fzc


==HIV-2 Gag Capsid from Immature Virus-like Particles==
<StructureSection load='8fzc' size='340' side='right'caption='[[8fzc]], [[Resolution|resolution]] 5.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8fzc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_2_(ISOLATE_ROD) Human immunodeficiency virus type 2 (ISOLATE ROD)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FZC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FZC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fzc OCA], [https://pdbe.org/8fzc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fzc RCSB], [https://www.ebi.ac.uk/pdbsum/8fzc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fzc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GAG_HV2RO GAG_HV2RO] Matrix protein p17 targets Gag and Gag-pol polyproteins to the plasma membrane via a multipartite membrane binding signal. Also mediates nuclear localization of the preintegration complex (By similarity).  Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex.  Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers (By similarity).  p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1.
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</StructureSection>
[[Category: Large Structures]]
[[Category: Mansky LM]]
[[Category: Talledge N]]
[[Category: Zhang W]]