View source for 8g87


==Human Oct4 bound to nucleosome with human nMatn1 sequence (focused refinement of Oct4 bound region)==
<StructureSection load='8g87' size='340' side='right'caption='[[8g87]], [[Resolution|resolution]] 8.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8g87]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8G87 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8G87 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 8.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8g87 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8g87 OCA], [https://pdbe.org/8g87 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8g87 RCSB], [https://www.ebi.ac.uk/pdbsum/8g87 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8g87 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PO5F1_HUMAN PO5F1_HUMAN] Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.<ref>PMID:18035408</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bilokapic S]]
[[Category: Du Y]]
[[Category: Halic M]]
[[Category: Malik D]]
[[Category: Sinha KK]]