View source for 8gcl


==Cryo-EM structure of hAQP2 in DDM==
<StructureSection load='8gcl' size='340' side='right'caption='[[8gcl]], [[Resolution|resolution]] 2.89&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8gcl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GCL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GCL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.89&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gcl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gcl OCA], [https://pdbe.org/8gcl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gcl RCSB], [https://www.ebi.ac.uk/pdbsum/8gcl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gcl ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/AQP2_HUMAN AQP2_HUMAN] Nephrogenic diabetes insipidus. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/AQP2_HUMAN AQP2_HUMAN] Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Fujiyoshi Y]]
[[Category: Kamegawa A]]
[[Category: Nishikawa K]]
[[Category: Numoto N]]
[[Category: Suzuki H]]
[[Category: Suzuki S]]