View source for 8gdl


==Acid phosphatase pseudoenzyme from flea==
<StructureSection load='8gdl' size='340' side='right'caption='[[8gdl]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8gdl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopsylla_cheopis Xenopsylla cheopis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GDL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GDL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PAM:PALMITOLEIC+ACID'>PAM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SRO:SEROTONIN'>SRO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gdl OCA], [https://pdbe.org/8gdl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gdl RCSB], [https://www.ebi.ac.uk/pdbsum/8gdl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gdl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A2IA89_9NEOP A2IA89_9NEOP] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The salivary glands of hematophagous arthropods contain pharmacologically active molecules that interfere with host hemostasis and immune responses, favoring blood acquisition and pathogen transmission. Exploration of the salivary gland composition of the rat flea, Xenopsylla cheopis, revealed several abundant acid phosphatase-like proteins whose sequences lacked one or two of their presumed catalytic residues. In this study, we undertook a comprehensive characterization of the tree most abundant X. cheopis salivary acid phosphatase-like proteins. Our findings indicate that the three recombinant proteins lacked the anticipated catalytic activity and instead, displayed the ability to bind different biogenic amines and leukotrienes with high affinity. Moreover, X-ray crystallography data from the XcAP-1 complexed with serotonin revealed insights into their binding mechanisms.

Acid phosphatase-like proteins, a biogenic amine and leukotriene-binding salivary protein family from the flea Xenopsylla cheopis.,Lu S, Andersen JF, Bosio CF, Hinnebusch BJ, Ribeiro JM Commun Biol. 2023 Dec 18;6(1):1280. doi: 10.1038/s42003-023-05679-0. PMID:38110569<ref>PMID:38110569</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 8gdl" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Xenopsylla cheopis]]
[[Category: Andersen JF]]
[[Category: Lu S]]
[[Category: Ribeiro JM]]