View source for 8gh5


==Implementing Logic Gates in DNA Crystal Engineering==
<StructureSection load='8gh5' size='340' side='right'caption='[[8gh5]], [[Resolution|resolution]] 2.64&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8gh5]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GH5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GH5 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.64&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gh5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gh5 OCA], [https://pdbe.org/8gh5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gh5 RCSB], [https://www.ebi.ac.uk/pdbsum/8gh5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gh5 ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
DNA self-assembly computation is attractive for its potential to perform massively parallel information processing at the molecular level while at the same time maintaining its natural biocompatibility. It has been extensively studied at the individual molecule level, but not as much as ensembles in 3D. Here, we demonstrate the feasibility of implementing logic gates, the basic computation operations, in large ensembles: macroscopic, engineered 3D DNA crystals. The building blocks are recently developed DNA double crossover-like (DXL) motifs. They can associate with each other via sticky-end cohesion. By encoding the inputs within the sticky ends of the motifs, we are able to realize common logic gates. The outputs are demonstrated through the formation of macroscopic crystals that can be easily observed. This study points to a new direction of construction of complex 3D crystal architectures and DNA-based biosensors with easy readouts. This article is protected by copyright. All rights reserved.

Implementing Logic Gates by DNA Crystal Engineering.,Zhang C, Paluzzi VE, Sha R, Jonoska N, Mao C Adv Mater. 2023 May 23:e2302345. doi: 10.1002/adma.202302345. PMID:37220213<ref>PMID:37220213</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Jonoska N]]
[[Category: Mao C]]
[[Category: Paluzzi VE]]
[[Category: Sha R]]
[[Category: Zhang C]]