View source for 8gkv


==Crystal structure of anti-adaptor IraP that regulates RpoS proteolysis==
<StructureSection load='8gkv' size='340' side='right'caption='[[8gkv]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8gkv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GKV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GKV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.351&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gkv OCA], [https://pdbe.org/8gkv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gkv RCSB], [https://www.ebi.ac.uk/pdbsum/8gkv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gkv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IRAP_ECOLI IRAP_ECOLI] Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS especially during phosphate starvation, but also in stationary phase and during nitrogen starvation. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway.<ref>PMID:16600914</ref> <ref>PMID:18383615</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Battesti A]]
[[Category: Gan J]]
[[Category: Gottesman S]]
[[Category: Ji X]]
[[Category: Shaw GX]]
[[Category: Suburaman P]]
[[Category: Wickner S]]
[[Category: Zhou YN]]