View source for 8gp6


==Structure of the vaccinia virus A16/G9 sub-complex from the orthopoxvirus entry-fusion complex==
<StructureSection load='8gp6' size='340' side='right'caption='[[8gp6]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8gp6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus_WR Vaccinia virus WR]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GP6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GP6 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gp6 OCA], [https://pdbe.org/8gp6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gp6 RCSB], [https://www.ebi.ac.uk/pdbsum/8gp6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gp6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PG094_VACCW PG094_VACCW] Component of the entry fusion complex (EFC), which consists of 11 proteins. During cell infection, this complex mediates entry of the virion core into the host cytoplasm by a two-step mechanism consisting of lipid mixing of the viral and cellular membranes and subsequent pore formation.<ref>PMID:16339313</ref> <ref>PMID:16973586</ref> <ref>PMID:34076488</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Vaccinia virus WR]]
[[Category: Lin S]]
[[Category: Lu GW]]
[[Category: Yang FL]]