View source for 8gpr


==GluK1-1a receptor captured in the desensitized state==
<StructureSection load='8gpr' size='340' side='right'caption='[[8gpr]], [[Resolution|resolution]] 8.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8gpr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GPR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GPR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 8.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gpr OCA], [https://pdbe.org/8gpr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gpr RCSB], [https://www.ebi.ac.uk/pdbsum/8gpr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gpr ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GRIK1_RAT GRIK1_RAT] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.<ref>PMID:16540562</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Dhingra S]]
[[Category: Kumar J]]