View source for 8grz


==X-ray crystal structure of V71C human neuroglobin mutant==
<StructureSection load='8grz' size='340' side='right'caption='[[8grz]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8grz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GRZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GRZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8grz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8grz OCA], [https://pdbe.org/8grz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8grz RCSB], [https://www.ebi.ac.uk/pdbsum/8grz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8grz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NGB_HUMAN NGB_HUMAN] Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.<ref>PMID:11029004</ref> <ref>PMID:11473128</ref> <ref>PMID:18416560</ref> <ref>PMID:21190290</ref> <ref>PMID:21296891</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Lin YW]]