View source for 8gs3


==Cryo-EM structure of human Neuroligin 3==
<StructureSection load='8gs3' size='340' side='right'caption='[[8gs3]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8gs3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GS3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GS3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gs3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gs3 OCA], [https://pdbe.org/8gs3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gs3 RCSB], [https://www.ebi.ac.uk/pdbsum/8gs3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gs3 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/NLGN3_HUMAN NLGN3_HUMAN] NON RARE IN EUROPE: Autism;NON RARE IN EUROPE: Asperger syndrome. Disease susceptibility is associated with variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/NLGN3_HUMAN NLGN3_HUMAN] Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system (By similarity).<ref>PMID:15620359</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Hou MZ]]
[[Category: Zhang HW]]
[[Category: Zhang ZZ]]