View source for 8gun


==Crystal structure of mutant H528A of EsaD from Staphylococcus aureus==
<StructureSection load='8gun' size='340' side='right'caption='[[8gun]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8gun]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_NCTC_8325 Staphylococcus aureus subsp. aureus NCTC 8325]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GUN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GUN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3000138&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gun OCA], [https://pdbe.org/8gun PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gun RCSB], [https://www.ebi.ac.uk/pdbsum/8gun PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gun ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ESSD_STAA8 ESSD_STAA8] Component of the type VII secretion system (Ess). Plays a role in Ess secretion during infection. Required for the efficient secretion of EsxA. Required for abscess formation and staphylococcal persistence in host tissues (By similarity). Possesses a toxic DNase activity that is modulated by EssG by forming a nuclease toxin-antitoxin pair. This nuclease toxin targets competitor bacteria (PubMed:27723728).[UniProtKB:A0A0H2XIV9]<ref>PMID:27723728</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Staphylococcus aureus subsp. aureus NCTC 8325]]
[[Category: Wang YJ]]
[[Category: Zhang ZM]]