View source for 8gyd


==Structure of Schistosoma japonicum Glutathione S-transferase bound with the ligand complex of 16==
<StructureSection load='8gyd' size='340' side='right'caption='[[8gyd]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8gyd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Schistosoma_japonicum Schistosoma japonicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GYD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GYD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0IH:(2R)-2-[[2-(5-chloranylthiophen-2-yl)-4-oxidanylidene-6-[2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]quinazolin-3-yl]methyl]-3-(4-chlorophenyl)propanoic+acid'>0IH</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gyd OCA], [https://pdbe.org/8gyd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gyd RCSB], [https://www.ebi.ac.uk/pdbsum/8gyd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gyd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GST26_SCHJA GST26_SCHJA] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.  GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.
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</StructureSection>
[[Category: Large Structures]]
[[Category: Schistosoma japonicum]]
[[Category: Hu H]]
[[Category: Jin R]]
[[Category: Lu X]]
[[Category: Song W]]
[[Category: Wen X]]
[[Category: Zhu J]]