View source for 8gyq


==Cryo-EM structure of human Pannexin-2 in pre-open state.==
<StructureSection load='8gyq' size='340' side='right'caption='[[8gyq]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8gyq]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GYQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gyq OCA], [https://pdbe.org/8gyq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gyq RCSB], [https://www.ebi.ac.uk/pdbsum/8gyq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gyq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PANX2_HUMAN PANX2_HUMAN] Ion channel with a slight anion preference (PubMed:36973289). Also able to release ATP (PubMed:36869038). Plays a role in regulating neurogenesis and apoptosis in keratinocytes (By similarity).[UniProtKB:Q6IMP4]<ref>PMID:36869038</ref> <ref>PMID:36973289</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cong Y]]
[[Category: Jin X]]
[[Category: Kong F]]
[[Category: Yan C]]