View source for 8gyt


==Cryo-EM structure of human Pannexin-3 R36S/F40R variant in pre-open state.==
<StructureSection load='8gyt' size='340' side='right'caption='[[8gyt]], [[Resolution|resolution]] 3.68&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8gyt]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GYT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GYT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.68&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gyt OCA], [https://pdbe.org/8gyt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gyt RCSB], [https://www.ebi.ac.uk/pdbsum/8gyt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gyt ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PANX3_HUMAN PANX3_HUMAN] Regulator of osteoblast differentiation by functionning as a Ca(2+) channel in the endoplasmic reticulum which regulates calmodulin (CaM) pathways. Allows ATP release into the extracellular space and activation or purinergic receptors.[UniProtKB:Q8CEG0]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cong Y]]
[[Category: Jin X]]
[[Category: Kong F]]
[[Category: Wu T]]
[[Category: Yan C]]