View source for 8hgh


==Structure of 2:2 PAPP-A.STC2 complex==
<StructureSection load='8hgh' size='340' side='right'caption='[[8hgh]], [[Resolution|resolution]] 4.16&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8hgh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HGH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HGH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.16&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hgh OCA], [https://pdbe.org/8hgh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hgh RCSB], [https://www.ebi.ac.uk/pdbsum/8hgh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hgh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.[https://www.uniprot.org/uniprot/PAPP1_HUMAN PAPP1_HUMAN] Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.<ref>PMID:10077652</ref> <ref>PMID:10913121</ref> <ref>PMID:11522292</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli K-12]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Chu HL]]
[[Category: Hang J]]
[[Category: Qiao J]]
[[Category: Wang GP]]
[[Category: Wei Y]]
[[Category: Zhang C]]
[[Category: Zhong QH]]