View source for 8hif


==One asymmetric unit of Singapore grouper iridovirus capsid==
<StructureSection load='8hif' size='340' side='right'caption='[[8hif]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8hif]] is a 144 chain structure with sequence from [https://en.wikipedia.org/wiki/Singapore_grouper_iridovirus Singapore grouper iridovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HIF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HIF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hif FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hif OCA], [https://pdbe.org/8hif PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hif RCSB], [https://www.ebi.ac.uk/pdbsum/8hif PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hif ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q5YFJ3_9VIRU Q5YFJ3_9VIRU] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Singapore grouper iridovirus (SGIV), one of the nucleocytoviricota viruses (NCVs), is a highly pathogenic iridovirid. SGIV infection results in massive economic losses to the aquaculture industry and significantly threatens global biodiversity. In recent years, high morbidity and mortality in aquatic animals have been caused by iridovirid infections worldwide. Effective control and prevention strategies are urgently needed. Here, we present a near-atomic architecture of the SGIV capsid and identify eight types of capsid proteins. The viral inner membrane-integrated anchor protein colocalizes with the endoplasmic reticulum (ER), supporting the hypothesis that the biogenesis of the inner membrane is associated with the ER. Additionally, immunofluorescence assays indicate minor capsid proteins (mCPs) could form various building blocks with major capsid proteins (MCPs) before the formation of a viral factory (VF). These results expand our understanding of the capsid assembly of NCVs and provide more targets for vaccine and drug design to fight iridovirid infections.

Near-atomic architecture of Singapore grouper iridovirus and implications for giant virus assembly.,Zhao Z, Huang Y, Liu C, Zhu D, Gao S, Liu S, Peng R, Zhang Y, Huang X, Qi J, Wong CCL, Zhang X, Wang P, Qin Q, Gao GF Nat Commun. 2023 Apr 12;14(1):2050. doi: 10.1038/s41467-023-37681-9. PMID:37041173<ref>PMID:37041173</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 8hif" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Singapore grouper iridovirus]]
[[Category: Gao GF]]
[[Category: Liu CC]]
[[Category: Qi JX]]
[[Category: Zhang XZ]]
[[Category: Zhao ZN]]
[[Category: Zhu DJ]]