View source for 8hle


==Structure of DddY-DMSOP complex==
<StructureSection load='8hle' size='340' side='right'caption='[[8hle]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8hle]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_bereziniae_NIPH_3 Acinetobacter bereziniae NIPH 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HLE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HLE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.91&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LNI:3-[dimethyl(oxidanyl)-$l^{4}-sulfanyl]propanoic+acid'>LNI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hle OCA], [https://pdbe.org/8hle PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hle RCSB], [https://www.ebi.ac.uk/pdbsum/8hle PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hle ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/N8X9V6_ACIBZ N8X9V6_ACIBZ] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Dimethylsulfoxonium propionate (DMSOP) is a recently identified and abundant marine organosulfur compound with roles in oxidative stress protection, global carbon and sulfur cycling and, as shown here, potentially in osmotolerance. Microbial DMSOP cleavage yields dimethyl sulfoxide, a ubiquitous marine metabolite, and acrylate, but the enzymes responsible, and their environmental importance, were unknown. Here we report DMSOP cleavage mechanisms in diverse heterotrophic bacteria, fungi and phototrophic algae not previously known to have this activity, and highlight the unappreciated importance of this process in marine sediment environments. These diverse organisms, including Roseobacter, SAR11 bacteria and Emiliania huxleyi, utilized their dimethylsulfoniopropionate lyase 'Ddd' or 'Alma' enzymes to cleave DMSOP via similar catalytic mechanisms to those for dimethylsulfoniopropionate. Given the annual teragram predictions for DMSOP production and its prevalence in marine sediments, our results highlight that DMSOP cleavage is likely a globally significant process influencing carbon and sulfur fluxes and ecological interactions.

DMSOP-cleaving enzymes are diverse and widely distributed in marine microorganisms.,Carrion O, Li CY, Peng M, Wang J, Pohnert G, Azizah M, Zhu XY, Curson ARJ, Wang Q, Walsham KS, Zhang XH, Monaco S, Harvey JM, Chen XL, Gao C, Wang N, Wang XJ, Wang P, Giovanonni SJ, Lee CP, Suffridge CP, Zhang Y, Luo Z, Wang D, Todd JD, Zhang YZ Nat Microbiol. 2023 Dec;8(12):2326-2337. doi: 10.1038/s41564-023-01526-4. Epub , 2023 Nov 29. PMID:38030907<ref>PMID:38030907</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 8hle" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Acinetobacter bereziniae NIPH 3]]
[[Category: Large Structures]]
[[Category: Li CY]]
[[Category: Peng M]]
[[Category: Zhang YZ]]