View source for 8huj


==Cryo-EM structure of the J-K-St region of EMCV IRES in complex with eIF4G-HEAT1 and eIF4A==
<StructureSection load='8huj' size='340' side='right'caption='[[8huj]], [[Resolution|resolution]] 3.76&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8huj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Encephalomyocarditis_virus Encephalomyocarditis virus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HUJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HUJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.76&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8huj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8huj OCA], [https://pdbe.org/8huj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8huj RCSB], [https://www.ebi.ac.uk/pdbsum/8huj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8huj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IF4A1_HUMAN IF4A1_HUMAN] ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.<ref>PMID:19153607</ref> <ref>PMID:19204291</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Encephalomyocarditis virus]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Fujiyoshi Y]]
[[Category: Imai S]]
[[Category: Shimada I]]
[[Category: Suzuki H]]