View source for 8ib8


==Human TRiC-PhLP2A-actin complex in the closed state==
<StructureSection load='8ib8' size='340' side='right'caption='[[8ib8]], [[Resolution|resolution]] 4.42&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8ib8]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IB8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IB8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.42&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ib8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ib8 OCA], [https://pdbe.org/8ib8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ib8 RCSB], [https://www.ebi.ac.uk/pdbsum/8ib8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ib8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PDCL3_HUMAN PDCL3_HUMAN] Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (PubMed:23792958, PubMed:26059764). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (PubMed:17429077). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (PubMed:15371430).[UniProtKB:Q4KLJ8]<ref>PMID:15371430</ref> <ref>PMID:17429077</ref> <ref>PMID:23792958</ref> <ref>PMID:26059764</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Kim H]]
[[Category: Lim S]]
[[Category: Park J]]
[[Category: Roh SH]]