View source for 8iff


==Cryo-EM structure of Arabidopsis phytochrome A.==
<StructureSection load='8iff' size='340' side='right'caption='[[8iff]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8iff]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IFF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IFF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=O6E:3-[2-[(~{Z})-[5-[(~{Z})-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-pyrrol-2-ylidene]methyl]-5-[(~{Z})-[(3~{R},4~{R})-3-ethyl-4-methyl-5-oxidanylidene-pyrrolidin-2-ylidene]methyl]-4-methyl-1~{H}-pyrrol-3-yl]propanoic+acid'>O6E</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8iff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8iff OCA], [https://pdbe.org/8iff PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8iff RCSB], [https://www.ebi.ac.uk/pdbsum/8iff PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8iff ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PHYA_ARATH PHYA_ARATH] Regulatory photoreceptor which exists in two forms that are reversibly interconvertible by light: the Pr form that absorbs maximally in the red region of the spectrum and the Pfr form that absorbs maximally in the far-red region. Photoconversion of Pr to Pfr induces an array of morphogenetic responses, whereas reconversion of Pfr to Pr cancels the induction of those responses. Pfr controls the expression of a number of nuclear genes including those encoding the small subunit of ribulose-bisphosphate carboxylase, chlorophyll A/B binding protein, protochlorophyllide reductase, rRNA, etc. It also controls the expression of its own gene(s) in a negative feedback fashion. Involved in the flowering time regulation. Can phosphorylate FHY1 and, possibly, FHL, in red light conditions; this inactivates their co-shuttling to the nucleus (PubMed:19208901). Regulates phototropic responses both in the nucleus (e.g. hypocotyl elongation and cotyledon opening under high-irradiance conditions and seed germination under very-low-fluence conditions) and in the cytoplasm (e.g. negative gravitropism in blue light and red-enhanced phototropism) (PubMed:17566111). Promotes seed germination, suppression of hypocotyl elongation, and randomization of hypocotyl growth orientation in far-red light; these responses to far-red light are repressed by UNE10/PIF8 (PubMed:31732705). Stabilizes UNE10/PIF8 but sequesters PIF3/PAP3 from its target genes promoters in far-red light (PubMed:31732705).<ref>PMID:12468726</ref> <ref>PMID:15707897</ref> <ref>PMID:17566111</ref> <ref>PMID:19208901</ref> <ref>PMID:19482971</ref> <ref>PMID:21969386</ref> <ref>PMID:31732705</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Large Structures]]
[[Category: Guan Z]]
[[Category: Ma L]]
[[Category: Wang J]]
[[Category: Yin P]]
[[Category: Zhou C]]