View source for 8ijp


==Structure of DNA binding domain of McrBC endonuclease bound to DNA: L68Y mutant==
<StructureSection load='8ijp' size='340' side='right'caption='[[8ijp]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8ijp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/DNA_molecule DNA molecule] and [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IJP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IJP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ijp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ijp OCA], [https://pdbe.org/8ijp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ijp RCSB], [https://www.ebi.ac.uk/pdbsum/8ijp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ijp ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MCRB_ECOLI MCRB_ECOLI] Recognizes N4- and C5-methylcytosine (and 5-hydroxy-methylcytosines) produced by a broad range of DNA methylases and appears to act against 5-methylcytosine preceded by a purine residue. Binds to DNA containing methylated cytosines; also binds to GTP. Isoform 33 kDa is less active than isoform 51 kDa and may play a role in regulating the activity of isoform 51 kDa by competing with it in DNA and protein binding abilities.
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</StructureSection>
[[Category: DNA molecule]]
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Adhav VA]]
[[Category: Saikrishnan K]]