View source for 8iom


==Crystal structure of the carboxy-terminal channel-forming domain of Colicin Ib==
<StructureSection load='8iom' size='340' side='right'caption='[[8iom]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8iom]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IOM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IOM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8iom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8iom OCA], [https://pdbe.org/8iom PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8iom RCSB], [https://www.ebi.ac.uk/pdbsum/8iom PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8iom ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A200P0K8_SHIFL A0A200P0K8_SHIFL] Colicins are polypeptide toxins produced by and active against E.coli and closely related bacteria.[ARBA:ARBA00003197]  This colicin is a channel-forming colicin. This class of transmembrane toxins depolarize the cytoplasmic membrane, leading to dissipation of cellular energy.[ARBA:ARBA00002178]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Shigella flexneri]]
[[Category: Hu NJ]]
[[Category: Yang J]]