View source for 8ipk


==The structure of human mitochondrial methyltransferase METTL15 with SAM==
<StructureSection load='8ipk' size='340' side='right'caption='[[8ipk]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8ipk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IPK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IPK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ipk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ipk OCA], [https://pdbe.org/8ipk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ipk RCSB], [https://www.ebi.ac.uk/pdbsum/8ipk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ipk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MET15_HUMAN MET15_HUMAN] N4-methylcytidine (m4C) methyltransferase responsible for the methylation of position C839 in mitochondrial 12S rRNA (PubMed:31665743, PubMed:32371392). Involved in the stabilization of 12S rRNA folding, therefore facilitating the assembly of the mitochondrial small ribosomal subunits (PubMed:31665743, PubMed:32371392).<ref>PMID:31665743</ref> <ref>PMID:32371392</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Lv MQ]]
[[Category: Zhou WW]]