View source for 8ite


==Crystal structure of pE301R from African swine fever virus==
<StructureSection load='8ite' size='340' side='right'caption='[[8ite]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8ite]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/African_swine_fever_virus African swine fever virus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=7drh 7drh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ITE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ITE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ite FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ite OCA], [https://pdbe.org/8ite PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ite RCSB], [https://www.ebi.ac.uk/pdbsum/8ite PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ite ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VF301_ASFB7 VF301_ASFB7] Plays a role in the inhibition of host innate immune system by acting as a negatively regulator of type I interferon production. Mechanistically, interacts with and prevents host IRF3 nuclear localization to inhibit its transcriptional activity.<ref>PMID:36099692</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: African swine fever virus]]
[[Category: Large Structures]]
[[Category: Li YH]]
[[Category: Zhang H]]