View source for 8iue


==RNA polymerase III pre-initiation complex melting complex 1==
<StructureSection load='8iue' size='340' side='right'caption='[[8iue]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8iue]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IUE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IUE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8iue FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8iue OCA], [https://pdbe.org/8iue PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8iue RCSB], [https://www.ebi.ac.uk/pdbsum/8iue PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8iue ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/RPAC1_HUMAN RPAC1_HUMAN] Hypomyelination-hypogonadotropic hypogonadism-hypodontia syndrome;Treacher-Collins syndrome. The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/RPAC1_HUMAN RPAC1_HUMAN] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and short non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs, respectively. POLR1C/RPAC1 is part of the polymerase core and may function as a clamp element that moves to open and close the cleft.[UniProtKB:P07703]<ref>PMID:20413673</ref> <ref>PMID:34671025</ref> <ref>PMID:34887565</ref> <ref>PMID:36271492</ref> <ref>PMID:26151409</ref> 

==See Also==
*[[Transcription initiation factors 3D structures|Transcription initiation factors 3D structures]]
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Hou H]]
[[Category: Jin Q]]
[[Category: Ren Y]]
[[Category: Wang Q]]
[[Category: Xu Y]]