View source for 8iup


==4-hydroxybutyryl-CoA Synthetase (ADP-forming) from Nitrosopumilus maritimus.==
<StructureSection load='8iup' size='340' side='right'caption='[[8iup]], [[Resolution|resolution]] 2.69&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8iup]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Nitrosopumilus_maritimus_SCM1 Nitrosopumilus maritimus SCM1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IUP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.69&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8iup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8iup OCA], [https://pdbe.org/8iup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8iup RCSB], [https://www.ebi.ac.uk/pdbsum/8iup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8iup ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HBCAL_NITMS HBCAL_NITMS] Involved in thaumarchaeal hydroxypropionate/hydroxybutyrate (HP/HB) cycle, a modified version of the autotrophic HP/HB cycle of Crenarchaeota. Catalyzes the formation of 4-hydroxybutyryl-CoA, ADP and phosphate from 4-hydroxybutyrate, coenzyme A (CoA) and ATP. Can also use acetate, propionate and butyrate, with poor catalytic efficiency.<ref>PMID:24843170</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Nitrosopumilus maritimus SCM1]]
[[Category: Demirci H]]
[[Category: Johnson J]]