View source for 8izn


==Structural study of Interferon-induced, double-stranded RNA-activated protein kinase (PKR) and Non-structural protein 1 (NS1) complex==
<StructureSection load='8izn' size='340' side='right'caption='[[8izn]], [[Resolution|resolution]] 6.67&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8izn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Memphis/102/1972(H3N2)) Influenza A virus (A/Memphis/102/1972(H3N2))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IZN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IZN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.67&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8izn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8izn OCA], [https://pdbe.org/8izn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8izn RCSB], [https://www.ebi.ac.uk/pdbsum/8izn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8izn ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/E2AK2_HUMAN E2AK2_HUMAN] Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection. In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity: phosphorylates CDK1 upon DNA damage. CDK1 phosphorylation triggers CDK1 polyubiquitination and subsequent proteolysis, thus leading to G2 arrest.<ref>PMID:20395957</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Han CW]]
[[Category: Kim HJ]]