View source for 8j8j


==Membrane bound PRTase, C3 symmetry, donor bound==
<StructureSection load='8j8j' size='340' side='right'caption='[[8j8j]], [[Resolution|resolution]] 2.76&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8j8j]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8J8J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8J8J FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.76&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PGW:(1R)-2-{[(S)-{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(HEXADECANOYLOXY)METHYL]ETHYL+(9Z)-OCTADEC-9-ENOATE'>PGW</scene>, <scene name='pdbligand=PRP:ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC+ACID'>PRP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8j8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8j8j OCA], [https://pdbe.org/8j8j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8j8j RCSB], [https://www.ebi.ac.uk/pdbsum/8j8j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8j8j ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DPPRS_MYCTU DPPRS_MYCTU] Involved in the biosynthesis of decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis (PubMed:15878857, PubMed:18310020). Catalyzes the transfer of a 5-phosphoribosyl residue from phosphoribose diphosphate (PRPP) to decaprenyl phosphate (DP) to form decaprenylphosphoryl-5-phosphoribose (DPPR) (PubMed:15878857, PubMed:18310020, PubMed:38491273). The enzyme favors polyprenyl phosphate with 50-60 carbon atoms, is unable to use C-20 polyprenyl phosphate, and uses C-75 polyprenyl phosphate less efficiently than C-50 or C-60 (PubMed:15878857). Cannot use UDP-galactose or GDP-mannose as a sugar donor (PubMed:15878857). May play a role in ethambutol (EMB) resistance (PubMed:25547657).<ref>PMID:15878857</ref> <ref>PMID:18310020</ref> <ref>PMID:25547657</ref> <ref>PMID:38491273</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Gao S]]
[[Category: Rao ZH]]
[[Category: Wu FY]]
[[Category: Zhang L]]