View source for 8jac


==Crystal structure of Mycobacterium tuberculosis LpqY in complex with trehalose analogue YB-16==
<StructureSection load='8jac' size='340' side='right'caption='[[8jac]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8jac]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JAC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JAC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=W4Z:N-[[(2R,3S,4S,5R,6S)-3,4,5,6-tetrakis(oxidanyl)oxan-2-yl]methyl]ethanamide'>W4Z</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jac OCA], [https://pdbe.org/8jac PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jac RCSB], [https://www.ebi.ac.uk/pdbsum/8jac PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jac ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LPQY_MYCTU LPQY_MYCTU] Part of the ABC transporter complex LpqY-SugA-SugB-SugC, which is highly specific for uptake of trehalose. Involved in the recycling of extracellular trehalose released from trehalose-containing molecules synthesized by M.tuberculosis. Trehalose uptake is essential for virulence.<ref>PMID:21118978</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Liang J]]
[[Category: Rao Z]]
[[Category: Zhang B]]