View source for 8jez


==Human sodium-dependent vitamin C transporter 1 in an apo inward-open state==
<StructureSection load='8jez' size='340' side='right'caption='[[8jez]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8jez]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JEZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JEZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AV0:Lauryl+Maltose+Neopentyl+Glycol'>AV0</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=LBN:1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine'>LBN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jez OCA], [https://pdbe.org/8jez PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jez RCSB], [https://www.ebi.ac.uk/pdbsum/8jez PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jez ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/S23A1_HUMAN S23A1_HUMAN] Sodium:ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate (PubMed:10556483, PubMed:10556521, PubMed:10631088, PubMed:36749388). Has retained some ancestral activity toward nucleobases such as urate, an oxidized purine. Low-affinity high-capacity sodium:urate cotransporter, may regulate serum urate levels by serving as a renal urate re-absorber (PubMed:36749388).<ref>PMID:10556483</ref> <ref>PMID:10556521</ref> <ref>PMID:10631088</ref> <ref>PMID:36749388</ref>   Inactive transporter.<ref>PMID:10556483</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Kobayashi TA]]
[[Category: Kusakizako T]]
[[Category: Nureki O]]