View source for 8jhk


==Cryo-EM structure of the DOCK5/ELMO1 complex, focused on one protomer==
<StructureSection load='8jhk' size='340' side='right'caption='[[8jhk]], [[Resolution|resolution]] 4.76&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8jhk]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JHK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JHK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.76&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jhk OCA], [https://pdbe.org/8jhk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jhk RCSB], [https://www.ebi.ac.uk/pdbsum/8jhk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jhk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ELMO1_HUMAN ELMO1_HUMAN] Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.<ref>PMID:11595183</ref> <ref>PMID:12134158</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Inoue M]]
[[Category: Ishizuka-Katsura Y]]
[[Category: Katsura K]]
[[Category: Kaushik R]]
[[Category: Kukimoto-Niino M]]
[[Category: Mishima-Tsumagari C]]
[[Category: Nakagawa R]]
[[Category: Shirouzu M]]
[[Category: Yonemochi M]]
[[Category: Zhang KYJ]]