View source for 8jjp


==G protein-coupled receptor 1==
<StructureSection load='8jjp' size='340' side='right'caption='[[8jjp]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8jjp]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JJP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JJP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jjp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jjp OCA], [https://pdbe.org/8jjp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jjp RCSB], [https://www.ebi.ac.uk/pdbsum/8jjp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jjp ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CML2_HUMAN CML2_HUMAN] Receptor for chemoattractant adipokine chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation and energy homesotasis (PubMed:18165312, PubMed:27716822). Signals mainly via beta-arrestin pathway. Binding of RARRES2 activates weakly G proteins, calcium mobilization and MAPK1/MAPK3 (ERK1/2) phosphorylation too (PubMed:27716822). Acts also as a receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity).[UniProtKB:Q8K087]<ref>PMID:18165312</ref> <ref>PMID:27716822</ref>   (Microbial infection) Coreceptor for HIV-1.<ref>PMID:10233994</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Chen G]]
[[Category: Liu A]]
[[Category: Liu Y]]
[[Category: Ye F]]