View source for 8jkd


==Cryo-EM structure of CCHFV envelope protein Gc trimer in complex with Gc13 Fab==
<StructureSection load='8jkd' size='340' side='right'caption='[[8jkd]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8jkd]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Crimean-Congo_hemorrhagic_fever_virus_strain_IbAr10200 Crimean-Congo hemorrhagic fever virus strain IbAr10200]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JKD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JKD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jkd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jkd OCA], [https://pdbe.org/8jkd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jkd RCSB], [https://www.ebi.ac.uk/pdbsum/8jkd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jkd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GP_CCHFI GP_CCHFI] Glycoprotein C and glycoprotein N interact with each other and are present at the surface of the virion. They are able to attach the virion to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Also promotes fusion of viral membrane with host endosomal membrane after endocytosis of the virion (By similarity).<ref>PMID:19088291</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Crimean-Congo hemorrhagic fever virus strain IbAr10200]]
[[Category: Large Structures]]
[[Category: Cao S]]
[[Category: Chong T]]