View source for 8jzl


==CryoEM structure of the Salmonella effector inositol phosphate phosphatase SopB==
<StructureSection load='8jzl' size='340' side='right'caption='[[8jzl]], [[Resolution|resolution]] 2.62&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8jzl]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JZL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.62&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jzl OCA], [https://pdbe.org/8jzl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jzl RCSB], [https://www.ebi.ac.uk/pdbsum/8jzl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jzl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SOPB_SALTY SOPB_SALTY] Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns 3-P and prevents the transition of PtdIns 3-P to PtdIns 3,5-P2. It is one of the known effectors injected by Salmonella into the host cell and is required for invasion and for an efficient generation and maintenance of Salmonella-containing vacuole (SVC). Alteration of the phosphoinositide composition of the plasma membrane causes membrane ruffling and actin cytoskeleton rearrangements. The persistence of PtdIns 3-P diverts the SCV from the endocytic pathway resulting in enlarged vesicles, which are essential to create a favorable environment where Salmonella can replicate and avoid immune defenses of the host cell.<ref>PMID:11244077</ref> <ref>PMID:11136447</ref> <ref>PMID:12360287</ref> <ref>PMID:15205533</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
[[Category: Cheng XQ]]
[[Category: Jiang WX]]
[[Category: Ma LX]]
[[Category: Wu M]]