View source for 8jzm


==The inhibitor of Toll-like receptor signaling o-vanillin binds covalently to MAL/TIRAP Lys-210==
<StructureSection load='8jzm' size='340' side='right'caption='[[8jzm]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8jzm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JZM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JZM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jzm OCA], [https://pdbe.org/8jzm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jzm RCSB], [https://www.ebi.ac.uk/pdbsum/8jzm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jzm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TIRAP_HUMAN TIRAP_HUMAN] Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.<ref>PMID:18292575</ref> <ref>PMID:19509286</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Jia X]]
[[Category: Kobe B]]
[[Category: Maxwell MJ]]
[[Category: Mobli M]]
[[Category: Rahaman MH]]