View source for 8jzt


==The sigF and anti-sigma factor complex==
<StructureSection load='8jzt' size='340' side='right'caption='[[8jzt]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8jzt]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JZT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JZT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jzt OCA], [https://pdbe.org/8jzt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jzt RCSB], [https://www.ebi.ac.uk/pdbsum/8jzt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jzt ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SIGF_MYCTU SIGF_MYCTU] Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Held in an inactive form by a cognate anti-sigma factor RsbW (UsfX) until released. Increased expression decreases growth rate, and after 3 days increases the expression of 51 loci encoding 33 protein-coding genes as well as some non-coding RNA (PubMed:22307756).<ref>PMID:12354223</ref> <ref>PMID:20729364</ref> <ref>PMID:22307756</ref> <ref>PMID:22570422</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Chen YJ]]
[[Category: Su D]]