View source for 8k1m


==mycobacterial efflux pump, apo state==
<StructureSection load='8k1m' size='340' side='right'caption='[[8k1m]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8k1m]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8K1M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8K1M FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=L9Q:(1S)-2-{[(S)-(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(OCTADECANOYLOXY)METHYL]ETHYL+(9Z)-OCTADEC-9-ENOATE'>L9Q</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8k1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8k1m OCA], [https://pdbe.org/8k1m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8k1m RCSB], [https://www.ebi.ac.uk/pdbsum/8k1m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8k1m ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MEPRM_MYCTU MEPRM_MYCTU] Probably part of the ABC transporter complex Rv1217c-Rv1218c involved in the resistance to a wide range of structurally unrelated drugs (PubMed:23143285). Probably responsible for the translocation of the substrate across the membrane (Probable).<ref>PMID:23143285</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Rao Z]]
[[Category: Wang Y]]
[[Category: Wu F]]
[[Category: Zhang L]]