View source for 8kbx


==Cryo-EM structure of human ATG2A-WIPI4 complex==
<StructureSection load='8kbx' size='340' side='right'caption='[[8kbx]], [[Resolution|resolution]] 3.23&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8kbx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8KBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8KBX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.23&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8kbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8kbx OCA], [https://pdbe.org/8kbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8kbx RCSB], [https://www.ebi.ac.uk/pdbsum/8kbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8kbx ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/WIPI4_HUMAN WIPI4_HUMAN] Infantile spasms syndrome;Beta-propeller protein-associated neurodegeneration. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/WIPI4_HUMAN WIPI4_HUMAN] Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:23435086, PubMed:28561066). Binds phosphatidylinositol 3-phosphate (PtdIns3P) (PubMed:28561066). Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes (PubMed:28561066). Together with WIPI1, promotes ATG2 (ATG2A or ATG2B)-mediated lipid transfer by enhancing ATG2-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31271352). Probably recruited to membranes through its PtdIns3P activity (PubMed:28561066).<ref>PMID:23435086</ref> <ref>PMID:28561066</ref> <ref>PMID:31271352</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Stjepanovic G]]
[[Category: Wang Y]]