View source for 8kcy


==Structure of nucleosome complexed with two DEK molecules==
<StructureSection load='8kcy' size='340' side='right'caption='[[8kcy]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8kcy]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8KCY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8KCY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8kcy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8kcy OCA], [https://pdbe.org/8kcy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8kcy RCSB], [https://www.ebi.ac.uk/pdbsum/8kcy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8kcy ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/DEK_HUMAN DEK_HUMAN] Note=A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with NUP214/CAN. It results in the formation of a DEK-CAN fusion gene.
== Function ==
[https://www.uniprot.org/uniprot/DEK_HUMAN DEK_HUMAN] Involved in chromatin organization.<ref>PMID:17524367</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Echigoya K]]
[[Category: Kujirai T]]
[[Category: Kurumizaka H]]
[[Category: Takizawa Y]]