View source for 8oes


==MUC5B amino acids 26-1435 Three beads==
<StructureSection load='8oes' size='340' side='right'caption='[[8oes]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8oes]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OES OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OES FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8oes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8oes OCA], [https://pdbe.org/8oes PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8oes RCSB], [https://www.ebi.ac.uk/pdbsum/8oes PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8oes ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/MUC5B_HUMAN MUC5B_HUMAN] Diffuse panbronchiolitis;Idiopathic pulmonary fibrosis;Hypersensitivity pneumonitis. Disease susceptibility is associated with variants affecting the gene represented in this entry. A common polymorphism in the promoter of MUC5B is associated with familial interstitial pneumonia and idiopathic pulmonary fibrosis, suggesting that dysregulated MUC5B expression in the lung may be involved in the pathogenesis of pulmonary fibrosis (PubMed:21506741).<ref>PMID:21506741</ref> 
== Function ==
[https://www.uniprot.org/uniprot/MUC5B_HUMAN MUC5B_HUMAN] Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus.
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Fass D]]
[[Category: Khmelnitsky L]]