View source for 8ogk


==Crystal structure of CdaA from Bacillus subtilis co-crystallized with DMSO==
<StructureSection load='8ogk' size='340' side='right'caption='[[8ogk]], [[Resolution|resolution]] 1.18&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8ogk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OGK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OGK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.18&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ogk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ogk OCA], [https://pdbe.org/8ogk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ogk RCSB], [https://www.ebi.ac.uk/pdbsum/8ogk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ogk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CDAA_BACSU CDAA_BACSU] One of 3 paralogous diadenylate cyclases (DAC) in this bacteria, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP) (Probable). Upon expression in E.coli leads to c-di-AMP synthesis (PubMed:23192352). Probably the main producer of c-di-AMP for the cell; is probably implicated in control of peptidogylcan synthesis (PubMed:22211522, PubMed:23192352, PubMed:26240071). In B.subtilis c-di-AMP is a second messenger that mediates growth, DNA repair and cell wall homeostasis; it is toxic when present in excess (PubMed:26240071).<ref>PMID:23192352</ref> <ref>PMID:26240071</ref> <ref>PMID:22211522</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Bacillus subtilis subsp. subtilis str. 168]]
[[Category: Large Structures]]
[[Category: Ficner R]]
[[Category: Garbers TB]]
[[Category: Neumann P]]