View source for 8oif


==Structure of the UBE1L activating enzyme bound to ISG15 and UBE2L6==
<StructureSection load='8oif' size='340' side='right'caption='[[8oif]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8oif]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OIF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OIF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8oif FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8oif OCA], [https://pdbe.org/8oif PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8oif RCSB], [https://www.ebi.ac.uk/pdbsum/8oif PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8oif ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/UBA7_HUMAN UBA7_HUMAN] E1-activating enzyme that catalyzes the covalent conjugation of the ubiquitin-like protein product of ISG15 to additional interferon stimulated proteins (ISGs) as well as other cellular proteins such as P53 in a process termed protein ISGylation (PubMed:27545325). Plays an essential role in antiviral immunity together with ISG15 by restricting the replication of many viruses including rabies virus, influenza virus, sindbis virus, rotavirus or human cytomegalovirus (PubMed:16254333, PubMed:19073728, PubMed:29056542, PubMed:29743376, PubMed:37722521). For example, ISG15 modification of influenza A protein NS1 disrupts the association of the NS1 with importin-alpha leading to NS1 nuclear import inhibition (PubMed:20133869). ISGylation of human cytomegalovirs protein UL26 regulates its stability and inhibits its activities to suppress NF-kappa-B signaling (PubMed:27564865).<ref>PMID:16254333</ref> <ref>PMID:19073728</ref> <ref>PMID:20133869</ref> <ref>PMID:27545325</ref> <ref>PMID:27564865</ref> <ref>PMID:29056542</ref> <ref>PMID:29743376</ref> <ref>PMID:37722521</ref> 

==See Also==
*[[3D structures of Ubiquitin activating enzyme|3D structures of Ubiquitin activating enzyme]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Kheewoong B]]
[[Category: Prabu JR]]
[[Category: Schulman BA]]
[[Category: Swatek KN]]
[[Category: Vollrath R]]
[[Category: Wallace I]]
[[Category: Von Gronau S]]