View source for 8oiv


==Monkeypox virus VP39 in complex with SAH and cap0==
<StructureSection load='8oiv' size='340' side='right'caption='[[8oiv]], [[Resolution|resolution]] 2.12&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8oiv]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Monkeypox_virus Monkeypox virus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OIV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OIV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.12&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTG:7-METHYL-GUANOSINE-5-TRIPHOSPHATE-5-GUANOSINE'>GTG</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8oiv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8oiv OCA], [https://pdbe.org/8oiv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8oiv RCSB], [https://www.ebi.ac.uk/pdbsum/8oiv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8oiv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MCE_MONPV MCE_MONPV] Displays methyltransferase, positive regulation of the poly(A) polymerase and transcription elongation activities. Involved in the modification of both mRNA ends and in intermediate and late gene positive transcription elongation. At the mRNAs 5' end, methylates the ribose 2' OH group of the first transcribed nucleotide, thereby producing a 2'-O-methylpurine cap. At the 3' end, functions as a processivity factor which stimulates the activity of the viral poly(A) polymerase OPG063 that creates mRNA's poly(A) tail. In the presence of OPG102, OPG063 does not dissociate from the RNA allowing tail elongation to around 250 adenylates.[UniProtKB:P07617]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Monkeypox virus]]
[[Category: Synthetic construct]]
[[Category: Boura E]]
[[Category: Chalupska D]]
[[Category: Klima M]]
[[Category: Silhan J]]
[[Category: Skvara P]]